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After a median observation period of approximately 6 years from first treatment, we examined the durability of remission, progression-free survival PFSoverall survival OSand safety outcomes of patients treated on this trial. Among patients who were on-study and in remission at study closure, 16 patients had not received any new treatment after single-agent brentuximab vedotin other than consolidative SCT. These finalwhich demonstrated a high rate of peripheral neuropathy resolution, and durable remissions in a subset of patients with relapsed or refractory systemic ALCL, provide pauline best dating free pro that single-agent brentuximab vedotin may be a potentially curative treatment option. This trial was registered at www. Brentuximab vedotin is an antibody-drug conjugate composed of an anti-CD30 chimeric antibody conjugated to the microtubule-disrupting agent, monomethyl auristatin E. Targeted delivery of monomethyl auristatin E to CDexpressing tumor cells is the primary mechanism of action, whereas additional proposed mechanisms of tumor cell killing that may contribute to the clinical activity of brentuximab vedotin include antibody-dependent cellular phagocytosis, immunogenic cell death, and the bystander effect.

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